Sodium 1-hydroxyethanesulphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well-documented, scientifically acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium 1-hydroxyethanesulphonate

EC Number:

213-037-4

EC Name:

Sodium 1-hydroxyethanesulphonate

Cas Number:

918-04-7

Molecular formula:

C2H6O4S.Na

IUPAC Name:

sodium 1-hydroxyethane-1-sulfonate

Details on test material:

Name of the test substance used in the study report: Acetaldehydbisulfit spezial

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Age at study start: about 6 - 8 weeks
Mean body weight at study start: 185 +/- 15 g
The animals were identified by toe amputation.
The animals were offered a standardized animal laboratory diet and tap water ad libitum during the observation period.
The animals were accommodated in fully air-conditioned rooms (temperature 22 + 2°C, humidity 55 + 5%) with a light/dark rhythm of 12 hours.
They were housed in groupe of five in cages of Becker, type D III resp. MD III, without bedding.

Administration / exposure

Route of administration:

other: dust-aerosol test

Type of inhalation exposure:

nose/head only

Vehicle:

air

Details on inhalation exposure:

Head-nose inhalation system; the animals are restrained in tubes and their snouts project into the inhalation chamber.
A mixture of dust and air was generated by means of dust metering equipment.
By means of a dust generator the substance to be tested was generated into a dust aerosol, which was passed into the inhalation system.
By means of an-exhaust air system the pressure ratios in the inhalation chamber were adjusted in such a way that the amount of fresh air was about 10% higher (excess pressure). This ensured that the mixture of test substance and air was not diluted by laboratory air in the breathing zones of the animals.

Duration of exposure:

4 h

Concentrations:

5.78 mg/l

No. of animals per sex per dose:

10

Control animals:

yes

Details on study design:

After the exposure period the surviving animals were observed for 14 days.
The body weight of the animais was checked before the beginning of the test, after 7 days and at the end of the observation period and was presented graphically. Clinical symptoms were recorded each workday. Mortality was checked each day.
At the end of the 14-day observation period the animals were sacrificed by CO2 and were subjected to a grosspathological examination.

Statistics:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5.8 mg/L air

Exp. duration:

4 h

Mortality:

None

Clinical signs:

other: During exposure: snout wiping After exposure: liquid up to reddened nasal secretion; the animals were without findings after one day.

Body weight:

Male animals: 191 g at study start; 278 g after 14 days
Female animals: 181 g at study start; 212 g after 14 days
No differences between control and exposure groups.

Gross pathology:

Sacrificed animals: nothing abnormal detected

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met