Registration Dossier
Registration Dossier
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EC number: 220-744-1 | CAS number: 2885-00-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Remarks:
- The cited reference lists the actual date of the unpublished report back in 1977 which is before the cut-off date of 2008.
Test material
- Reference substance name:
- Octadecane-1-thiol
- EC Number:
- 220-744-1
- EC Name:
- Octadecane-1-thiol
- Cas Number:
- 2885-00-9
- Molecular formula:
- C18H38S
- IUPAC Name:
- octadecane-1-thiol
- Test material form:
- solid: bulk
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- Not specified
- Observation period (in vivo):
- Over 24 hours
- Duration of post- treatment incubation (in vitro):
- Not specified
- Number of animals or in vitro replicates:
- Not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 2
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 2
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 2
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 2
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of mild irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Due to the mild irritation exhibited during the test and was reversible following 24 hours after its application then it has been deemed to be non-irritating based on GHS classification criteria.
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