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EC number: 943-133-8
CAS number: -
The test substance is considered to be
mutagenic in the Salmonella typhimurium/Escherichia coli reverse
mutation assay in the presence of metabolic activation.
Mean revertants per plate
In a GLP compliant study, performed
according to OECD guideline 471, the mutagenic potential of the
test substance was evaluated in the bacterial strains S. typhimurium TA
1535, TA 1537, TA 98 and TA 100 and E. coli WP2 uvr A with and without
metabolic activation (rat liver S9 mix). Concentrations from 33
up to 5000 μg/plate were tested in triplicate in the standar plate test.
Precipitation of the test substance was found from about 333 μg/plate
onward with and without S9 mix. A bacteriotoxic effect was observed
depending on the strain and test conditions from about 1000 μg/plate
onward. A biologically relevant increase in the number of his+ or trp+
revertants (factor ≥ 2: TA 100 and TA 98 or factor ≥ 3: TA 1535 and TA
1537) was not observed in the standard plate test using tester strains
TA 1535, TA 100, TA 1537 and E. coli WP2 uvrA with and without S9 mix.
Furthermore, using tester strain TA 98 without metabolic activation no
relevant increase in the number of his+ revertants was observed in
standard plate test. Using tester strains TA 98, a reproducible increase
in the number of his+ revertants exceeding a factor of 2 compared to the
concurrent vehicle control was observed after the addition of a
metabolizing system. Increase at concentrations of 2500 and 5000
μg/plate in the 1st Experiment and at concentrations of 1000 up to 5000
μg/plate in the 2nd Experiment was observed using tester strain TA 98
with S9 mix. Under the experimental conditions of this study, the test
substance is mutagenic in the Salmonella typhimurium/Escherichia coli
reverse mutation assay in the presence of metabolic activation.
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