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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977/78
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Smyth H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1960)
GLP compliance:
no
Test type:
other: BASF Method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
EC Number:
221-897-7
EC Name:
Anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
Cas Number:
3271-76-9
Molecular formula:
C31H15NO3
IUPAC Name:
anthra[2,1,9-mna]naphth[2,3-h]acridine-5,10,15(16H)-trione
Test material form:
liquid
Details on test material:
Vat Green 3

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Inhalation of a saturated atmosphere at ambient temperature (20°C). To achieve saturation, 200L air per hour was fed through an approx. 5 cm deep layer of the product.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
saturation concentration
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observation, weekly weighing
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Statistics:
NA

Results and discussion

Preliminary study:
NA
Effect levels
Sex:
not specified
Dose descriptor:
LC0
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: no effect at saturation concentration
Mortality:
no deaths
Clinical signs:
other: no effects
Body weight:
no data
Gross pathology:
no effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
7 hours inhalation of a with test item saturated atmosphere did not lead to any deaths in rats