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EC number: 267-956-0
CAS number: 67953-76-8
Summary of findings.
Nominal concentrations (ul/L/ppm)
Result expressed as nominal concentration. Properties of the
test substance and evidence from other studies (where
concentrations were measured) indicate that nominal and
measured concentrations are likely to be in good agreement.
LC50 corrected for density (1.1) and % active acid (9.42%),
LC50 values: 24 h - >32,000 <56,000; 48 h - 23,202; 96 h - 17,044 ppm
LC50 values: 24
h - >3316 <5803; 48 h - 2402; 96 h - 1766 mg/L
1. Percentage immobilisation at 24 and 48 h.
Concentration (mg active acid/L)
Immobilisation – average of 3 replicates (%)
are expressed as nominal concentration. Properties of the test
substance and evidence from other studies (where concentrations were
measured) indicate that nominal and measured concentrations are likely
to be in good agreement.
pH for higher concentrations (resulting from acidic nature of test
material) could be responsible for much of the observed toxicity.
However the results still indicate a low degree of short-term toxicity.
(48 h) EC50 527 mg/L D. magna (r-a) as HEDP-H
(96 h) LC50 1770 mg/L P. pugio (r-a) as HEDP-H (EG&G,
No reliable data are available determining the toxicity of HEDP-xK to
The key studies have been
read-across to HEDP potassium salts from HEDP-H.
The resulting EC50
once read-across taking into account ionisation state and MW, will be
higher for the phosphonic sodium and potassium salts than for the acid.
The results of tests conducted
on HEDP and its salts are directly comparable, because the ionisation
state will depend only on the pH of the test medium. The counterion is
not considered to contribute to effects in fish. At
environmentally-relevant pH values, HEDP will be ionised typically three
times, and will form stable complexes with metal ions.
Data are available assessing the
short-term toxicity effects of HEDP sodium salts to invertebrates,
however the study with the lowest reliable results in terms of HEDP acid
have been selected as key, even if conducted on HEDP-H.
A 48 h EC50 value of
527 mg active acid/L has been determined for the effects of HEDP acid
(CAS 2809-21-4) on the immobility of Daphnia magna (Monsanto,
1981). This is the lowest reliable value available for this endpoint and
has been selected as key.
The pH in the test medium was
below acceptable levels in the exposure treatments (the pH of
the test media ranged between 2.0 in the highest test
concentration to 8.2 in the lowest). However the pH was within
acceptable ranges in the controls and this study still suggests a very
low level of HEDP toxicity towards D. magna.
Other studies show EC50
values between 750 mg/L (estimated) and 3.3 g/L.
A 96 h LC50 value of
1770 mg/L (active acid) has been determined for the effects of HEDP-H on
the mortality of the marine shrimp Paleomontes pugios (EG&G,
1976). This is the lowest reliable value available for this
endpoint and has been selected as key.
An estuarine study is available
indicating an LC50 value of >=960mg/L with Unio
tumidus (Henkel, 1979).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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