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EC number: 943-154-2
CAS number: -
The substance was examined for the ability to induce gene mutations in
tester strains of Salmonella typhimurium and Escherichia coli, as
measured by reversion of auxotrophic strains to prototrophy. The five
tester strains TA1535, TA1537, TA98, TA100 and WP2 uvrA were used.
Experiments were performed both in the absence and presence of metabolic
activation, using liver S9 fraction from rats pre-treated with
Phenobarbital and 5,6-Benzoflavone. The test item was used as a solution
in sterile water for injection.
Toxocity test was performed as to establish correct doses for the main
test, with plate incorporation method. In this first main assay toxicity
was observed for all dose levels but TA1535 with activation system.
In the second main assay some dose levels were decresed and
pre-incubation step was added since no relevant increase in the number
of revertant was observed. However, severe to slight toxicity was again
observed and a thrid main assya was performed with lower dose levels.
The substance did not induce reverse mutation of Salmonella T. or
Escherichia Coli in the absence or presence of S9 metabolism under the
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