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EC number: 943-154-2
CAS number: -
The median effect concentration (EC50)
and the no-effect concentration (NOEC) of analogue substance to Daphnia
magna were investigated under static exposure conditions over a
period of 48 h, following guideline OECD 202.
Since the test item is well soluble,
the media were prepared by respective dilutions of a stock solutions.
The investigated nominal concentration
were 100, 45.5, 20.7, 3.39, 4.27 and 1.94 mg/l.
40 individual Daphnia divided
into 2 test vessels were exposed to each concentration of the test item,
and 60 Daphnia divided into 3 test vessels were used as blank
The concentrations of test item in the
test medium were measured by DOC analysis at the beginning and after 24
and 48 h of exposure. The analyses revealed that the test item was
completely dissolved. However, the concentrations tended to decrease
over the 48 h incubation period and did not remain within the 80-120% of
the nominal concentration. Consequently, the effective concentrations (ECx)
were assessed based on the geometric mean of the measured
The 48 h EC50of analogue
substance to Daphnia magnais 3.17 mg/l (95% confidence interval:
3.41–4.63 mg/l). This result is based on measured concentrations.
All validity criteria were fulfilled.
EC50, 48h; Daphnia Magna, static test, OECD 202 = 3.17 mg/l
The analogue substance was tested for short-term toxicity to aquatic
invertebrates following OECD 202 (Ricci, 2016). Under the experimental
conditions the EC50, 48h is equal to 3.17 mg/l.
Based on the read across considerations same results apply to target
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