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EC number: 219-616-8
CAS number: 2481-94-9
Genetic toxicity in vitro for
4-(Diethylamino) azobenzene was assessed for its possible mutagenic
potential .For this purpose Salmonella-microsome assay was performed on
Salmonella typhimurium strainTA1535, TA1537 and TA1538,using test
substance concentration of 0-1000µg/plate (4.44µmol/plate).The test
substance was exposed to the Salmonella typhimurium strainTA1535, TA1537
and TA1538 in the presence and absence of metabolic activation system.S9
mix, Adult male Sprague-Dawley rats (200- 250 g) pre-treated with
Aroclor 1254 (500 mg/kg) were used to obtain liver for the metabolic
activation system. The strains were checked periodically for relevant
genetic markers and for rfa by crystal violet sensitivity.Each
experiment included solvent controls as well as known direct-acting
mutagens and a mutagen that required metabolic activation. No mutagenic
effects were observed during the study. Therefore4-(Diethylamino)
azobenzene was considered to be non mutagenic in Salmonella typhimurium
strainTA1535, TA1537 and TA1538 by AMES assay. Hence it cannot be
classified as gene mutant in vitro.
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