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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from GSBL

Data source

Reference
Reference Type:
secondary source
Title:
Range-Finding Toxicity Data, List V
Author:
GSBL
Year:
1996
Bibliographic source:
German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Hexylamine in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexylamine
EC Number:
203-851-8
EC Name:
Hexylamine
Cas Number:
111-26-2
Molecular formula:
C6H15N
IUPAC Name:
hexan-1-amine
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): Hexylamine
- Molecular formula (if other than submission substance): C6H15N
- Molecular weight (if other than submission substance): 101.191 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Weight at study initiation: 90-120g
Fasting period before study: Not fasted before dosing

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
VEHICLE
Concentration in vehicle: 25% in water
Amount of vehicle (if gavage):between 1 -10ml
Justification for choice of vehicle: an aqueous solution of 25% Na 3,9-diethyl6-tridecanolsulfat was dissolved in water, corn oil or 1% Tergitol 7 Penetrant dissolved.
Doses:
No data
No. of animals per sex per dose:
5 male
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?): 14 days
Statistics:
LD50 value and range of confidence were determined by the Thompson method (Bacteriol Rev. 11, 1947, p. 115) using the tables of Weil (Biometrics 8, 1952, p 249).

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
670 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in treated male rats.
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.
Executive summary:

In a acute oral toxicity study, Wistar male rats by using Hexylamine orally by gavage and observed for 14 days. 50 % mortality was observed in treated male rats at 670 mg/kg bw. Therefore, LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.