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EC number: -
CAS number: -
Summary Considering the physico-chemical properties of FAT 40849, [i.e.,
high molecular weight for organic salts (above 1000), small log POW
value (-3.2), and low vapor pressure of 2.16 x 10-31 Pa at 25 °C
(estimate)], absorption of FAT 40849 from various routes of exposure,
such as oral, dermal or inhalation is expected. However, absorption of
FAT 40849 is expected to mainly occur via oral (50% absorption rate) and
inhalation routes (100% absorption rate), but with limited potential for
dermal absorption (10% absorption rate can be expected). The results of
the 28-day repeated oral toxicity study also provided the evidence that
the organic components of FAT 40849 may not cross the blood-brain
barrier (BBB) upon oral exposure to cause CNS effects. Retaining of
small particles in the deep lungs may not be excluded due to the
substance physico-chemical properties. Following absorption, FAT 40849
is anticipated to be distributed at the very least to the digestive
tract, kidneys, lungs, thymus, mesenteric lymphnodes, testes, prostrate,
uterus and vagina, based on the discoloration effects noted in these
organs in animals following repeated oral exposure. However, deposition
of test material in these organs may be unlikely to cause toxicity
concern based on the results of the 28-day test, reproductive toxicity
screening and prenatal studies which displayed no test item
treated-related adverse effects in the dosed animals (NOAELs oral, rat ≥
1000 mg/kg bw were observed for all the repeated toxicity studies). The
constituents of FAT 40849 having large molecular weight may be
metabolized in the liver and consequently excreted via bile. On the
other hand, the inorganic salts/ions may be excreted mainly through
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