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EC number: -
CAS number: -
No significant inhalation exposure is expected. Therefore the
hazard assessment of FAT 40849/A TE for human health is driven mainly by
the strong skin sensitisation property for which respective risk
management measures have to be implemented (see “Guidance on information
requirements and chemical safety assessment Part E: Risk
Characterisation, chapter 3.4”). No adverse target organ toxicity was
seen after repeated oral exposure. The determination of a dermal DNEL
based on the NOAEL derived from the oral study is therefore
scientifically not justified. Risk management measures should therefore
rather be based on the skin sensitisation properties following “Guidance
on information requirements and chemical safety assessment Part E: Risk
Characterisation, chapter 3.4”.
The information available from a developmental
toxicity/teratogenicity study conducted according to OECD 414 (Takawale,
BSL, 103759, 2011, RL1, chapter 7.8.2) does not disagree with this
conclusion in reporting a NOAEL for both maternal toxicity and fetal
toxicity of FAT 40849/C TE in Wistar rats of 1000 mg/kg bw/day.
See above under workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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