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EC number: -
CAS number: -
96h LC50 > 100 mg/L96h NOEC >= 100 mg/l
No data on the Short Term Toxicity to fish
of the substance is available. The results from the structural analogue
are used instead (for details see reporting Format as attached to
section 13 in the IUCLID dossier).
Two data are available for this endpoint.
In the first study (Safepharm, 1992), the
acute toxicity of the test substance Reaction mass of tetrasodium
hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate to Rainbow trout was
determined in a 96-hour semi-static limit test according to the method
C.1 of EEC Directive 84/449 (previous version of the EEC Directive
92/69), OECD Guideline No. 203 (1984) and GLP.
nominal test substance concentration tested was 100 mg/L. A control
group was tested in parallel.
the start and the end of the test, the analytically determined
concentrations of the test substance in the test media were between 89.5
and 96.2% of the nominal values. Thus, it was demonstrated that the test
substance was stable during the test period, and the reported biological
results are based on the nominal test substance concentrations.
no mortality was observed during the exposition period, the 96-hour
LC50 of Reaction mass of tetrasodium phosphonoethane-1,2-dicarboxylate
and hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate was > 100 mg/L and
the 96 -hour NOEC of Reaction mass of tetrasodium
hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate was >= 100 mg/L.
on these results, Reaction mass of tetrasodium
hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate should not be
considered as harmful to the aquatic organisms tested.
second study available (Kurume Laboratory, 2000) is a
preliminary test of a bioaccumulation study. The acute toxicity
of the test substance Reaction mass of tetrasodium
hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate to Oryzias
latipes was determined in a 96-hour semi-static test
according to a Japanese Industrial Standard.
nominal test substance concentrations tested were 198, 296, 444, 667 and
1000 mg/L. A control group was tested in parallel.
analytical monitoring has been performed.
the test substance concentration of 1000 mg/L, 100% mortality was
observed at 24 hours.
At the test
substance concentration of 667 mg/L, 40% mortality was observed at 24
hours, 60% mortality was observed at 48, 72 and 96 hours
For the other test
substance concentrations (i.e. 198, 296 and 444 mg/L) and control, no
mortality has been observed.
96-hour LC50 of Reaction mass of tetrasodium
hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate was determined to be
the first study (Safepharm, 1992) has been performed according to the
OECD and EU guidelines, following the GLP, and that the validity
criteria were fulfilled, this study is considered as reliable without
restrictions. Moreover, among the two studies available, it gives the
most conservative result, therefore is selected as key study.
The second study
(Kurume Laboratory) is considered as reliable with restrictions because,
even if the method is acceptable, some details on test method are
lacking and no analytical monitoring has been performed. As the result
obtained is consistent with the key study, it has been selected as
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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