Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available - Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
Piperidine, 1-formyl-; N-Formylpiperidin; Formylpiperidine; N-Formylpiperidine; 1-Formylpiperidine; NFP; 1-Piperidinecarboxaldehyde; Piperidinoformamide
Author:
Canadian Centre for Occupational Health and Safety
Year:
2010
Bibliographic source:
Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010

Materials and methods

Principles of method if other than guideline:
database data, no information is given on test method
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Piperidine-N-carbaldehyde
EC Number:
219-986-0
EC Name:
Piperidine-N-carbaldehyde
Cas Number:
2591-86-8
Molecular formula:
C6H11NO
IUPAC Name:
piperidine-1-carbaldehyde
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report) : Piperidine, 1-formyl-
- RTECS Number : TN0380000
- Synonyms/Trade Names : N-Formylpiperidin , Formylpiperidine , N-Formylpiperidine , 1-Formylpiperidine , NFP , 1-Piperidinecarboxaldehyde , Piperidinoformamide

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Details on exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
No details available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
300 mg/kg bw
Based on:
not specified
Remarks on result:
other: Reference : BDCGAS Berichte der Deutschen Chemischen Gesellschaft. (Leipzig, Ger. Dem. Rep.) V.1-61, 1868- 1928. For publisher information, see CHBEAM. Volume(issue)/page/year: 34,2408,1901
Mortality:
No details available
Clinical signs:
No details available
Body weight:
No details available
Gross pathology:
No details available
Other findings:
Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Executive summary:

For the substance Piperidine, 1-formyl- a LDLo of 300 mg/kg bw in the rabbit (sex not specified) is reported. (Reference : BDCGAS Berichte der Deutschen Chemischen Gesellschaft. (Leipzig, Ger. Dem. Rep.) V.1-61, 1868- 1928. For publisher information, see CHBEAM. Volume(issue)/page/year: 34,2408,1901)