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EC number: 943-097-3
CAS number: -
Individual Body Weight and Clinical Observations
Body Weight (g)
Individual Skin Reaction on Induction Sites
Maximum score (Erythema / Edema)
0 / 1
2 / 3
2 / 2
4 / 4
4 / 3
0 / 0
2 / 1
3 / 3
1 / 1
3 / 4
1 / 2
4 / 4
Individual Sensitization Observation
using the procedures outlined in the QPS Taiwan Study Plan for
T65316012-IR which is based on the SOP for the OECD 406 (CTPS-TE00516)
and OECD 406 (OECD, 1992). The results of this OECD 406 test for CJ313
show that test reliability criteria was met.
A 10% and 25% CJ313 was used for intradermal injection and
occlusively patched, respectively, to ten test guinea pigs to induce
water for injection was used for similar injection and occlusively
patched to five control guinea pigs. Following a recovery period,
animals received a challenge patch with 2.5% CJ313.
The skin sensitization reactions were scored at approximately 24 and 48
hours after patch removal. At the end of study, body weight increase was
observed in all animals. During 48 hours after challenge exposure, 30%
treated animals showed sensitization to the CJ313. Under the conditions
of this study, CJ313 caused moderate sensitization in guinea pigs.
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