Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The toxicity of inhaled ethylene oxide and propylene oxide vapors; acute and chronic toxicity of ethylene oxide and acute toxicity of propylene oxide
Author:
Jacobson KH, Hackley WB, Feinsilver L.
Year:
1956
Bibliographic source:
AMA Arch Ind Health 13(3):237-44

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
4 124 mg/m³ air
Based on:
test mat.

Applicant's summary and conclusion