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EC number: 201-121-3
CAS number: 78-50-2
A study was
conducted to evaluate the eye irritation potential of the test substance
in rabbits according to OECD Guideline 405, in compliance with GLP. Test
substance (0.1 mL, which is equivalent to 61.3 mg) was instilled in one
eye of three New Zealand White rabbits with the help of a syringe-type
applicator. The contralateral eye served as control. The treated and
control eyes of each rabbit were examined for irritation of the cornea,
iris and conjunctiva at 1, 24, 48 and 72 h following instillation of the
test substance. The eye was examined with the aid of an ultraviolet
light source. Ocular reactions were graded according to the numerical
Draize technique. Toxicity and pharmacological effects were recorded at
each ocular observation period and mortality was checked daily. All
animals were humanely sacrificed using C02following study
termination. There was no corneal opacity or iritis noted at any
observation period. Conjunctival irritation, seen all animals, cleared
in one eye by 24 h and in the other two by 72 h. The control eyes
appeared normal at all observation periods. No abnormal physical signs
were recorded. Under the study conditions, the test substance was not
irritating to eyes (Hall DA, 2010).
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