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EC number: 201-121-3
CAS number: 78-50-2
Primary Irritation Index (PDII) was calculated by adding mean
erythema/eschar and edema values on the 4 h exposure, of all animals at
24 and 72 h (a total of 4 values) and dividing the sum by 2.
Calculation of Modified Primary Irritation Index (PDII):
Mean erythema scores
Mean edema scores
of Mean Scores =7.00
Primary Irritation Index (PDII) = Sum of Mean Scores/2 = 3.50
A study was
conducted to evaluate the skin irritation potential of the test
substance in rabbits according to OECD Guideline 404, in compliance with
GLP. 0.5 g of test substance was moistened with 0.5 mL of distilled
water to form a pasty consistency and applied at each test site under a
2.5 x 2.5 cm gauze patch, using semi-occlusive conditions. After an
exposure period of 4 h, the wrappings and patches were removed and the
sites gently washed with distilled water. The test sites were scored for
signs of dermal irritation at 1, 24, 48 and 72 h as well as on Day 7, 14
and 17 after removal of the patches. Erythema and edema were scored
according to the numerical Draize technique. The skin was also evaluated
for ulceration and necrosis or any evidence of tissue destruction.
Additional clinical signs were noted. Under the study conditions, the
test substance was found to be irritating to skin (DiDonato LJ, 2010).
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