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EC number: 201-121-3
CAS number: 78-50-2
A study was
conducted to determine the acute oral toxicity of the read across
substance ‘A mixture of: hexyldioctylphosphineoxide;
dihexyloctylphosphineoxide; trioctylphosphineoxide’ in male and female
Sprague-Dawley rats. The substance was administered by gavage to each of
ten rats at a level of 5,000 m/kg bw. Animals were observed for external
signs of toxicity, body weights and mortality. All animals that died
prematurely and those sacrificed at termination of the study were
subjected to a gross necropsy and all abnormalities were noted. All
animals survived the 15 d post-administration observation period.
Diarrhea, salivation, decreased activity, wet abdomen, sore-rectal area,
hair loss at abdomen was observed in both males and females. Nasal
discharge was observed in one mail. Swollen and sore hind legs were
observed in one female. Mean body weight increased as compared to
initial. No noteworthy findings were observed in gross pathology. Under
the study conditions, the acute oral LD50 was found to be
>5,000 mg/kg bw (Reagan EL, 1985).
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