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Toxicity to aquatic algae and cyanobacteria

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A growth inhibition test was performed to evaluate the toxicity of the test substance to alga, Selenastrum capricornutum, according to OECD Guideline 201, in compliance with GLP. In this test, 3 replicates, each containing approximately 1.0 E4 cells/mL were exposed to water accommodated fractions (WAFs) of the test substance at nominal concentrations of 0, 1, 50, 100, 200 and 300 mg/L (equivalent to measured concentrations of 0, 0, 0, 1.29 and 3.98 mg/L, respectively) under static conditions for a period of 96 h. Growth (biomass) and growth rate were recorded at 72 and 96 h. Calculations were performed based on nominal loading rates as well as the calculated measured concentrations of test substance. The analytical concentration of the test substance was measured by the Dissolved Organic Carbon (DOC) method. Under the study conditions, the NOEC and LOEC values for both growth rate and growth (biomass) were 1 and 50 mg/L, respectively, based on nominal loading rates. The 96 h ErC50 was 238 mg/L (nominal), equivalent to a measured concentration of 1.53 mg/L. The 96 h EbC50was 162 mg/L, based on nominal loading rate, equivalent to a measured concentration of 1.87 mg/L (Bragin GE, 1993c).