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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure not according to a defined method, but data reproducible and scientifically acceptable
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1949
Reference Type:
publication
Title:
Range finding toxicity data: List VI
Author:
Smyth, Jr. H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C. and Striegel, J.A.
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23:95-107

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene
Details on test material:
- Name of test material (as cited in study report): Ethylbenzene
- Physical state: liquid
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: 719
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
not specified in the report

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
not specified in the report
Duration of treatment / exposure:
24 hour(s)
Observation period:
not specified in the report
Number of animals:
5
Details on study design:
The skin irritation method employed in this study is non-standard. The irritation is based on the severest reaction which occurs on the shorn ventral skin of 5 albino rabbits 24 hours after the uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10).

Results and discussion

In vivo

Results
Irritation parameter:
other: non-standard skin irritation
Time point:
other: 24 hr
Score:
4
Max. score:
6
Remarks on result:
other: Uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10)
Irritant / corrosive response data:
not specified in the report
Other effects:
not specified in the report

Any other information on results incl. tables

No data was available.

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Ethyl benzene is considered a moderate skin irritant (grade 4).
Executive summary:

Ethylbenzene was evaluated for dermal irritation in rabbits and based under the conditions of the study was graded as Grade 4 (moderate skin irritant).