Registration Dossier
Registration Dossier
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EC number: 201-325-2 | CAS number: 81-11-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data came from the HPV dossier (IUCLID 4 file) on CAS No. 81-11-8 that was posted on the OECD website.
Data source
Reference
- Reference Type:
- publication
- Title:
- Uterotropic action in rat of amsonic acid and three of its synthetic precursors.
- Author:
- Smith ER and Quinn MM
- Year:
- 1 992
- Bibliographic source:
- J. Toxicol. Environ. Health. 36(1), 13-25.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- EC Number:
- 201-325-2
- EC Name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- Cas Number:
- 81-11-8
- Molecular formula:
- C14H14N2O6S2
- IUPAC Name:
- 2,2'-ethene-1,2-diylbis(5-aminobenzenesulfonic acid)
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- no data
- Doses:
- 3000 mg/kg bw
1000 mg/kg bw - No. of animals per sex per dose:
- 3000 mg/kg bw: 6
1000 mg/kg bw: 15 - Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 000 mg/kg bw
- Mortality:
- Two out of six animals given 3000 mg/kg i.p. died within 24 hours of
treatment. None of the 15 animals given 1000 mg/kg died. - Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- LD50 (male)= 3000 mg/kg bw
- Executive summary:
According to publsihed data LD50 (male)= 3000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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