Registration Dossier
Registration Dossier
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EC number: 201-325-2 | CAS number: 81-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data came from the SIDS dossier on CAS No. 81-11-8 that was accepted at SIAM 4 and posted on the OECD website.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- Principles of method if other than guideline:
- no details given
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- EC Number:
- 201-325-2
- EC Name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- Cas Number:
- 81-11-8
- Molecular formula:
- C14H14N2O6S2
- IUPAC Name:
- 2,2'-ethene-1,2-diylbis(5-aminobenzenesulfonic acid)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The rats were housed in groups of 3-6 animals and were allowed free access to food and water.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Single oral doses of 1000 or 3000 mg/kg were given to an unlisted number of animals.
- Doses:
- Single oral doses of 1000 or 3000 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Toxicity was assessed 24 hour after application.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: No signs of toxicity were noted.
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as harmful/toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- LD50 (male) > 3000 mg/kg bw
- Executive summary:
The acute oral toxicity study was conducted by using the given test chemical in Male Sprague-Dawley rats at the concentrations of 1000 and 3000 mg/kg bw. No signs of toxicity were noted.
LD50 (male) > 3000 mg/kg bw
Based on the study results, the substance is considered to be not toxic to rats via oral application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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