Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology updates. Dimethylsulfoxide
- Author:
- Willhite CC, Katz PI
- Year:
- 1 984
- Bibliographic source:
- J. Appl. Toxicol., 4(3), 155-60
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- skin irritation / corrosion
- eye irritation
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Results and discussion
- Results:
- In humans, topical and intradermal application of DMSO produced garlic breath, mast cell degranulation, an increase in polymorphonuclear leukocytes and perivascular eosinophils, itching, and histamine mediated and non-histamine dependent whealing and erythematous flare.
Two drops of >50% DMSO in the eye caused a temporary burning sensation and vasodilatation; concentrations of 50% exhibited no effects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
