Potassium 2-ethylhexanoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP, non-guideline, limitations in design and/or reporting

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexanoic acid

EC Number:

205-743-6

EC Name:

2-ethylhexanoic acid

Cas Number:

149-57-5

IUPAC Name:

2-ethylhexanoic acid

Details on test material:

Purity: 99,6 %

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Laboratories, Kingston, NY
- Age at study initiation: 8 weeks
- Weight at study initiation: 106-124 g


ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71-75
- Humidity (%): 51-52
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg b.w.

Doses:

0, 90, 722, 1445, 2890 mg/kg b.w.

No. of animals per sex per dose:

4

Control animals:

yes

Details on study design:

Animals were observed several times during the first 24 hours after dosing and once each workday thereafter for the duration of the test
(a total of 14 calendar days). Body weights were collected on the day of dosing and 1, 2, 3, 7, and 14 days after dosing.
All animals were necropsied . Animals which died after administration of the test article were necropsied promptly . All animals surviving the scheduled observation period were euthanetized and necropsied 14 days after test article administration.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

2 043 mg/kg bw

Based on:

test mat.

95% CL:

1 445 - 2 890

Mortality:

Dose (mg/kg b.w.):
90 mg/kg b.w.: 0/4
722 mg/kg b.w.: 0/4
1445 mg/kg b.w.: 0/4
2890 mg/kg b.w.: 4/4

Clinical signs:

other: weakness (90, 722, 1445 mg/kg b.w.) prostration (2890 mg/kg b.w.)

Gross pathology:

90, 722 and 1445 mg/kg b.w. dose groups: no treatment-related changes were observed. No tissue was collected for microscopic examination.
2890 mg/kg b.w.: the cause of death for rats dying after exposure to the test material was not determined. Treatment-related changes consisted of compuond present in the duodenum(1/4), jejunum (3/4), ileum (3/4), cecum (4/4), colon (4/4) and fecal discoloration (1/4) and wetness (1/4) of the inguinal hair.