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Environmental fate & pathways

Bioaccumulation: terrestrial

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Link to relevant study record(s)

Description of key information

GLP/Guideline-compliant 56 day earthworm study.
Published studies in quail.

Key value for chemical safety assessment

BCF (terrestrial species):
5.1 dimensionless

Additional information

The bioaccumulation potential of TBBPA in terrestrial species was investigated in earthworms and quail:

1) Aufderheide et al. (2003): Earthworms (Eisenia fetida) were subjected to continual TBBPA exposure for 28 days at concentrations of 0.562, 1.16, 2.11, 4.50, 9.01, 16.7 and 35.4 mg TBBPA/kg of dry soil. Measured tissue concentration declined with increasing soil concentration. After 28 days, measured concentrations of TBBPA in worm tissues were <0.250 (control), 2.86, 0.279, 0.394, 0.456, 0.453, 0.611 and 0.677 µg TBBPA per gram of tissue. The bioaccumulation factors for the treatment worms decreased from 0.24 to 0.02 for the worms exposed to 1.16 to 35.4 mg TBBPA /kg dry soil. The bioaccumulation factor (BSAF) was 5.1 for worms exposed to 0.562 mg TBBPA/kg d soil. Although the bioaccumulation factor of the lowest treatment level was greater than 1, the decrease in bioaccumulation factors with increasing soil concentration suggests that TBBPA did not bioaccumulate within the worm tissues during the 28-day exposure.

2) Halldin et al. (2001): The potential for TBBPA to affect reproduction variables in adult Japanese quail (Cortunix japonica) following in ovo exposure as well as TBBPA’s distribution in eggs, embryos and laying birds was investigated using 14C-labelled material. Uptake of 14C-TBBPA was studied in 6- and 9-day-old quail embryos following egg-injection (1.9 µg/g egg) on day 3; TBBPA’s distribution in quail embryos (1.9 µg/g egg) and adult females (oral and intravenous, 250 µg/bird) was studied following a single dose. The potential for effects on male sexual behaviour, testis weight, plasma testosterone concentration, egg-laying, and gross morphology of the oviducts was evaluated in adult birds following embryonic exposure (15 µg/g egg).

The embryonic uptake of TBBPA was low (<1% of the radiolabel) after yolk injection on day 3 of incubation. Laying quail rapidly eliminated TBBPA (and any metabolites) after oral or intravenous administration via bile and faeces. Transfer to egg yolk was low. Thus, TBBPA was readily excreted by the laying females as well as by the growing embryo, and consequently, the risk for embryonic exposure following dietary intake in laying birds is expected to be low.