(2-methoxymethylethoxy)propanol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

Method: BASF test
PROCEDURE
Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test).
White Vienna rabbits were used. Usually, 2 animals were treated for 5 minutes and for 2 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid or powdered and moistened test substance. In addition, skin tissue from the ear was tested by wrapping the ear. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal / lateral flank of the back.

After the application time, the skin was washed with water which sometimes contained a mild detergent.

The animals were observed 5 days and skin changes were recorded on working days.

The report usually describes findings after 24 hours and at the end of the observation period. Thus, for final evaluation, the findings after 48 hours and 5 days from the raw data have to be taken into account.
The original BASF grading was converted into the numerical grading according to the OECD Draize system.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

(2-methoxymethylethoxy)propanol

EC Number:

252-104-2

EC Name:

(2-methoxymethylethoxy)propanol

Cas Number:

34590-94-8

Molecular formula:

C7H16O3

IUPAC Name:

2-[(1-methoxypropan-2-yl)oxy]propan-1-ol

Details on test material:

- Name of test material (as cited in study report): Methoxypropoxypropanol
- Physical state: liquid
- Substance number: 78/187
- Vapour pressure (20°C): 0.4 Torr

Test animals

Species:

rabbit

Test system

Type of coverage:

occlusive

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 1 ml
- Concentration (if solution): undiluted

Duration of treatment / exposure:

Exposure times: 5 min and 2 hours

Observation period:

up to 5 days

Number of animals:

2 (1 male, 1 female)

Details on study design:

TEST SITE
- Area of exposure: 2.5 x 2.5 cm

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 24 h, 48 h and 5 d

Score:

0

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24 h, 48 h and 5 d

Score:

0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Classification: not irritating