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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Qualifier:
according to guideline
Guideline:
EU Method B.2 (Acute Toxicity (Inhalation))
Qualifier:
according to guideline
Guideline:
other: TSCA-Guideline §798.1150
GLP compliance:
yes
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl phosphate
EC Number:
201-114-5
EC Name:
Triethyl phosphate
Cas Number:
78-40-0
Molecular formula:
C6H15O4P
IUPAC Name:
triethyl phosphate
Details on test material:
Purity: 99,83%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
other: whole body (except tail)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
1400; 3360; 8817 mg/m3 air.
No. of animals per sex per dose:
5/sex/dose
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 8 817 mg/m³ air
Exp. duration:
4 h
Mortality:
No mortalities.
Clinical signs:
other: 3360 mg/m³ = untended fur, diminuated motility, miosis, bloody snout. 8817 mg/m³ = untended fur, piloerection, diminuated motility ,ataxia, miosis, diminuated breathing, accelerated breathing.
Body weight:
Marginal retardation in weight gain in male rats in the first week in groups with 3360 mg/m³ and 8817 mg/m³.
Gross pathology:
No signs of organ damages.

Any other information on results incl. tables

Akute inhalation toxicity-aerosol

 Concentration nomin.analyt. mg/m³ air  Toxicological result   Duration of symptoms  Timepoint of death  Particle < 3 µm (%)
 rat (male)               
 Air-control    0/0/5*  --  --  -
 21200  1400  0/0/5  --  --  60
 53000  3360  0/5/5  4h-1d  --  21
 106000  8817  0/5/5  4h-4d  --  22
 rat (female)               
 Air-control   0/0/5  --  --  -
 21200  1400  0/0/5  --  --  60
 53000  3360  0/5/5  4h-6h  --  21
 106000  8817  0/5/5  4h-2d  --  22

LC50: > 8817 mg/m³ air

* = No.of mortalities/ No.of animals with symptoms/ No.of animals used

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information
Executive summary:

In an acute inhalation toxicity study in rats performed according to OECD 403 triethyl phosphate showed no acute inhalation toxicity.

Clinical signs observed in the 3360 mg/m³ air group were: untended fur, diminuated motility, miosis, bloody snout and in the 8817 mg/m³ air group: untended fur, piloerection, diminuated motility ,ataxia, miosis, diminuated breathing, accelerated breathing.

Marginal retardation in weight gain in male rats in the first week could be remarked at 3360 mg/m³ and 8817 mg/m³ air.

The LC50 was > 8817 mg/m³ air.

The NOEL was 1400 mg/m³ 4h air.