Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-279-3 | CAS number: 80-43-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For dicumyl peroxide no substance specific data on metabolism and kinetics are available. According to information from the German MAK Commission, organic peroxides are inactivated by glutathione (GSH) peroxidases and converted to less toxic metabolites (DFG, 1992). In the case of dicumyl peroxide this metabolism would result in 2-phenyl-2-propanol (CAS 617-94-7). This substance was investigated in the EU risk assessment for cumene (European Commission, 2001), as it is formed during metabolism after oral and inhalation exposure. 2-phenyl-2-propanol is eliminated from the body through excretion in the urine. Besides the unconjugated 2-phenyl-2-propanol the major metabolites found in urine were its glucuronide and/or sulphate conjugates. From a structurally related substance benzoyl peroxide it is know that this organic peroxide penetrates unchanged through the stratum corneum or follicular openings of excised human skin and is converted metabolically to benzoic acid within the skin (OECD, 2004). Studies in rhesus monkey supported by information from humans indicate that there is no evidence of parental benzoyl peroxide in the systemic circulation. The renal clearance of the systemically absorbed metabolite is so rapid that it precludes passage through the liver. Therefore, no systemic toxicity due to accumulation can be expected. It is expected that dicumyl peroxide will behave in a similar way and that further investigations on distribution and metabolism are not regarded necessary for risk assessment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
