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EC number: 201-279-3 | CAS number: 80-43-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In an acute toxicity test using Daphnia magna dicumyl peroxide showed no effects up to maximum water solubility.
Key value for chemical safety assessment
Additional information
No effects of dicumyl peroxide were observed in Daphnia magna under semi-static conditions based on immobilization. In a test performed according to OECD guideline 202, Daphnia were exposed to 100 mg/L (nominal), measured 0.388 mg/L. No effects were observed over a period of 48 h. Therefore, it can be concluded that dicumyl peroxide exhibits no acute effects up to maximum water solubility.
A further study was performed in accordance with OECD guideline 202 (Daphnia sp. acute immobilisation test) and EU method C.2 (acute toxicity for Daphnia). No toxic effects were observed at any concentration, including the maximum water soluble concentration of 1.74 mg/L. The maximum water soluble concentration was determined to be 1.74 mg/L based on non-purgeable organic carbon (NPPOC) analyses. Since the NPOC analysis is not a specific analysis for the test compound, the results can only be used as an indication of the concentration.
The 48–hr acute EC50 of dicumyl peroxide to Daphnia magna under semi-static conditions based on immobilisation was 0.420 mg/L. The test concentrations were prepared using rather high concentrations of solvent and were verified by HPLC analysis. The 48–hr NOEC based on immobilization was 0.289 mg/L. The effects may be related to impurities present in higher amounts in the test solutions due to the use of solvent. As the test was performed with solvent the result cannot be regarded as valid for classification and labelling purposes.
In conclusion, data from acute toxicity testing towards Daphnia indicate that dicumyl peroxide showed no effects at water solubility.
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