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EC number: 201-251-0
CAS number: 80-10-4
No in vitro/vivo data are available for skin irritation/corrosion or eye irritation. However, based on the fact that this substance is a chlorosilane, so generates hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin irritation study and eye irritation study (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Dichloro(diphenyl)silane hydrolyses very
rapidly (half-life 10 seconds at pH 7)
in contact with water and moist air, releasing 2 moles of hydrogen
chloride (HCl) for each mole of parent material. Although no in
vitro/vivo irritation/corrosion studies are available, severe skin, eye
and respiratory damage can be expected due to release of HCl. This is
consistent with reliable measured data for other chlorosilanes.
classified as Skin Corrosive Category 1A with the hazard statement H314
‘Causes severe skin burns and eye damage’ according to Regulation
are no experimental data for respiratory tract irritation. The
additional hazard statement EUH071 ‘Corrosive to the respiratory tract'
(Regulation (EC) 1272/2008) is proposed in accordance with anticipated
respiratory tract damage due to the hydrolysis product HCl generated by
chlorosilanes on contact with moisture.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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