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EC number: 201-251-0
CAS number: 80-10-4
No studies are available. Based on molecular structure, molecular
weight, water solibility, and octanol-water partition coefficient it can
be expected that the submission substance is likely to be absorbed via
the oral, dermal, and inhalation routes. Hydrolysis occurs rapidly, and
systemic exposure is expected to both the parent substance and the
hydrolysis product. Based on the water solubility, the registered
substance and its silanol-containig hydrolysis product are likely to be
distributed in the body, and excretion via the renal pathway can be
expected. Bioaccumulation is not expected.
are no studies available in which the toxicokinetic properties of
dichloro(diphenyl)silane have been investigated. Therefore, the
toxicokinetic behaviour assessment of the substance and its hydrolysis
product was assessed by its physico-chemical properties.
hydrolyses rapidly in contact with water (half-life 10 seconds at pH 7
and 1.5°C), generating hydrogen chloride (HCl) and
diphenylsilanediol.The substance would also hydrolyse rapidly in contact
with moist skin; the resulting HCl hydrolysis product would be severely
irritating or corrosive. It is therefore likely that any systemic
exposure to the substance will be to the hydrolysis product,
diphenylsilanediol, rather than the parent substance,
dichloro(diphenyl)silane. Therefore, this toxicokinetic behaviour
assessment will try to predict the behaviour of the hydrolysis product
molecular weight, predicted water solubility and log Kow of
diphenylsilanediol are 216.3 g/mol, 580 mg/l and 2.00, respectively. The
moderate log Kow (2.00) and water solubility (580 mg/l) of
the hydrolysis product suggest it will have the potential to efficiently
pass through biological membranes by passive diffusion.
ingestion occurs, the hydrolysis of the parent substance at the low pH
of the stomach will be very rapid (T1/2 of 6 seconds at pH4), so any
absorption of the parent substance is expected to be negligible and it
is more likely to be the hydrolysis product that is absorbed. The
predicted moderate water solubility (580 mg/l) of the hydrolysis product
suggests it will readily dissolve in the gastrointestinal fluids. Also,
the low molecular weight (216.3 g/mol) of diphenylsilanediol suggests
that it may have the potential to pass through aqueous pores or be
carried through the epithelial barrier by the bulk passage of water.
Furthermore, the moderate log Kow (2.00) of
diphenylsilanediol indicates it is likely to be absorbed by passive
diffusion. There are no reliable studies to check for signs of oral
moderate water solubility (580 mg/l) and log Kow (2.00) of
diphenylsilanediol suggest that absorption via the dermal route is
possible. However, the molecular weight of 216.3 g/mol indicates that
the potential for absorption by the dermal route will be limited. QSAR
based dermal permeability prediction (DERWIN V2.00.2009) using molecular
weight, log Kow and water solubility, calculated a dermal
penetration rate 1.69E-03 mg/cm2/h for diphenylsilanediol.
This suggests that dermal penetration of the hydrolysis product,
diphenylsilanediol, will be very low. Since the other hydrolysis
product, HCl is corrosive to the skin; damage to the skin might increase
penetration. There are no reliable studies to check for signs of dermal
vapour pressure of the parent substance (0.078 Pa) indicates that
inhalation of the registered substance as a vapour will be minimal or
negligible. The moderate log Kow (2.00) and water solubility
(580 mg/l) of the hydrolysis product suggest that absorption from the
respiratory tract epithelium by passive diffusion is likely. As with
dermal exposure, damage to membranes caused by the corrosive nature of
the HCl hydrolysis product might enhance the uptake. There are no
reliable studies to check for signs of inhalation toxicity.
low molecular weight (216.3 g/mol) and moderate water solubility of
diphenylsilanediol suggest that it will have the potential to diffuse
through aqueous channels, pores and will be widely distributed. The log Kow
of 2.00 indicates it is likely to be distributed into cells and
therefore the intracellular concentration will be higher than the
extracellular concentration. Hydrogen and chloride ions will enter the
body’s natural homeostatic processes.
hydrolyses very rapidly to form diphenylsilanediol and HCl. There are no
data regarding the enzymatic metabolism of dichloro(diphenyl)silane or diphenylsilanediol.
Genetic toxicity test in vitro showed no observable differences in
effects with and without metabolic activation for
dichloro(diphenyl)silane and the read-across substance
low molecular weight and good water solubility of the hydrolysis product
suggest that they are likely to be excreted by the kidneys into urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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