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EC number: 201-251-0
CAS number: 80-10-4
are no adequate data regarding the repeated dose toxicity of
dichloro(diphenyl)silane or its hydrolysis product diphenylsilanediol,
therefore data from the other hydrolysis product HCl is considered
appropriate to determine local DNELs for the parent substance.
Dichloro(diphenyl)silane hydrolyses very rapidly (half-live of 10
seconds at pH 7) in contact with moist air and in contact with tissues
to form 2 moles of hydrogen chloride (HCl) and one mole of
diphenylsilanediol. Local effects (corrosion) are therefore influenced
by the formation of HCl.
exposure –Local effects:
each mole of dichloro(diphenyl)silane (molecular weight 253.19) produces
two moles of HCl (molecular weight 36.46), it is appropriate to
calculate the starting concentration of dichloro(diphenyl)silane that
would result in an exposure concentration of 8 mg/m3
HCl, assuming complete hydrolysis.
equivalent exposure level expressed as parent dichloro(diphenyl)silane
is calculated as:
(HCl) = 36.46 g/mol
dichloro(diphenyl)silane = 253.19 g/mol
HCl produced by 1 mole dichloro(diphenyl)silane =
2 x 36.46 g/mol = 68.92 g. Concentration of dichloro(diphenyl)silane required
to produce 8 mg/m3 HCl = (253.19/68.92)*8 = 29.39 mg/m³.
additional assessment factors are applied to the OEL.
The RMMs in place due to the corrosivity of
the substance will prevent dermal exposure.
DNEL (Long-term exposure - local effects, worker): 29.39 mg/m3
term exposure – Systemic effects
of the corrosivity of the substance, the DNEL for local effects is
considered sufficiently protective against potential systemic effects.
EU long-term inhalation Occupational Exposure Limit (OEL) has been set
for HCl as 8 mg/m3 (8 h TWA) in Commission
SIDS Initial Assessment Report (SIAR) for HCl describes a systemic NOAEL
of 20 ppm from a 90-day repeated dose inhalation study (OECD, 2002).
However, since the NOAEL for local effects in the same study was 10 ppm
it is considered by the author of this CSR that the observed effects at
20 ppm were secondary to corrosion.
is therefore considered appropriate to use the existing EU OEL for HCl
as the starting point to quantify local DNELs for
is no potential for exposure of consumers via any route to
dichloro(diphenyl)silane, therefore DNELs for consumers are not
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