Sodium lactate

Boiling point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

November, 1941

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 103 (Boiling Point/Boiling Range)

Deviations:

not specified

GLP compliance:

no

Type of method:

ebulliometer

Specific details on test material used for the study:

In this experimental study the boiling points of solutions of Sodium lactate with different concentrations in water have been determined. Crystalline Sodium lactate is hygroscopic and extremely difficult to isolate, thus only manufactured and marketed as a concentrated aqueous solution..
The concentrations of the Sodium lactate solutions are 5 %, 10 %, 20 %, 30 %, 40 %, 50 %, 60 % and 70 %.

Boiling pt.:

99.75 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 5 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

100.11 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 10 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

101.43 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 20 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

103.31 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 30 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

105.53 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 40 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

108.73 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 50 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

112.88 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 60 % (w/w) solution of Sodium lactate in water.

Boiling pt.:

119.43 °C

Atm. press.:

742 mm Hg

Decomposition:

no

Remarks on result:

other: 70 % (w/w) solution of Sodium lactate in water.

Conclusions:

The boiling point of different concentrated aqueous solutions of Sodium lactate were determined by the ebulliometer method. As a result the following boiling points for the different Sodium lactate concentrations in water have been determined:
5 % (w/w) Sodium lactate in water: b.p. = 99.75 °C;
10 % (w/w) Sodium lactate in water: b.p. = 100.11 °C;
20 % (w/w) Sodium lactate in water: b.p. = 101.43 °C;
30 % (w/w) Sodium lactate in water: b.p. = 103.31 °C;
40 % (w/w) Sodium lactate in water: b.p. = 105.53 °C;
50 % (w/w) Sodium lactate in water: b.p. = 108.73 °C.
60 % (w/w) Sodium lactate in water: b.p. = 112.88 °C.
70 % (w/w) Sodium lactate in water: b.p. = 119.43 °C.

Executive summary:

In this experimental study, which is comparable to an OECD 103 (ebulliometer method), the boiling points of different aqueous solutions of Sodium lactate have been determined. "Pure" Sodium lactate is not available as the substance has very strong hygroscopic properties and is therefore marketed as a concentrated solution.

Consequently, the following boiling points for the different Sodium lactate concentrations in water were determined at 742 mm Hg:

5 % (w/w) Sodium lactate in water: b.p. = 99.75 °C;

10 % (w/w) Sodium lactate in water: b.p. = 100.11 °C;

20 % (w/w) Sodium lactate in water: b.p. = 101.43 °C;

30 % (w/w) Sodium lactate in water: b.p. = 103.31 °C;

40 % (w/w) Sodium lactate in water: b.p. = 105.53 °C;

50 % (w/w) Sodium lactate in water: b.p. = 108.73 °C.

60 % (w/w) Sodium lactate in water: b.p. = 112.88 °C.

70 % (w/w) Sodium lactate in water: b.p. = 119.43 °C.

Reference 2

Endpoint:

boiling point

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2022-11-16

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

The test item Sodium lactate is only available and marketed as concentrated aqueous solution due to the substance's hygroscopic properties. Experimental determination of the boiling point of an aqueous solution is not reasonable because the result will be highly influenced by the boiling point of water (see supporting information). Therefore, the boiling point of the test item is estimated by QSAR prediction. Please refer to QPRF/QMRF documentation for detailed information on model suitability.

Qualifier:

according to guideline

Guideline:

other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals

Version / remarks:

May 2008

Principles of method if other than guideline:

QSAR prediction using MPBPVP v1.43 of EpiSuite v4.1.

GLP compliance:

no

Type of method:

other: QSAR calculation.

Specific details on test material used for the study:

Canonical: CC(C(=O)[O-])O.[Na+]
Stereoisomers do exist. The input of the respective canonical SMILES for Sodium (S)-lactate and Sodium (R)-lactate all result in identical QSAR predictions. Stereochemistry is not expected to influence boiling point predictions for the different lactates.

Key result

Boiling pt.:

436.66 °C

Remarks on result:

other: Adapted Stein and Brown Method.

See QPRF/QMRF.

Conclusions:

Estimated boiling points from MPBPWIN can only be recommended for screening purposes. However, due to the substance’s hygroscopic properties, the test item Sodium lactate is only available and marketed as aqueous solution and therefore the boiling point estimation for the “pure” substance using the MPBPVP methodology is considered adequate for a regulatory conclusion. The estimated boiling point for Sodium lactate is 436.66 °C.

Executive summary:

Crystalline Sodium lactate has hygroscopic properties and is extremely difficult to isolate. Therefore, the substance is only manufactured and marketed as a concentrated aqueous solution. It can be concluded that the experimental determination of the boiling point of an aqueous solution of Sodium lactate is not representative for the "pure" substance as it will be highly influenced by the boiling point of pure water. Therefore, a QSAR estimation using MPBPVP v1.43 of EpiSuite v4.1 is considered to be more practical in this case. The estimated boiling point for "pure" Sodium lactate is 436.66 °C and the substance is considered to be in the applicability domain of the model. MPBPVP methodology is considered adequate for a regulatory conclusion.

Description of key information

The QSAR estimation using MPBPVP v1.43 of EpiSuite v4.1 resulted in a boiling point of 436.66 °C for Sodium lactate.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

436.66 °C

Additional information

Crystalline Sodium lactate has strong hygroscopic properties and is extremely difficult to isolate. Therefore, the substance is only manufactured and marketed as a concentrated aqueous solution. It can be concluded that the experimental determination of the boiling point of an aqueous solution of Sodium lactate is not representative for the "pure" substance as it will be highly influenced by the boiling point of pure water. Therefore, a QSAR estimation using MPBPVP v1.43 of EpiSuite v4.1 is considered to be more practical in this case. The estimated boiling point for "pure" Sodium lactate is 436.66 °C and the substance is considered to be in the applicability domain of the model. MPBPVP methodology is considered adequate for a regulatory conclusion.

Supporting information on this endpoint can be derived from an experimental study, comparable to an OECD 103 study (ebulliometer method), in which the boiling points of different concentrated aqueous solutions of Sodium lactate were determined at 742 mm Hg:

5 % (w/w) Sodium lactate in water: b.p. = 99.75 °C;

10 % (w/w) Sodium lactate in water: b.p. = 100.11 °C;

20 % (w/w) Sodium lactate in water: b.p. = 101.43 °C;

30 % (w/w) Sodium lactate in water: b.p. = 103.31 °C;

40 % (w/w) Sodium lactate in water: b.p. = 105.53 °C;

50 % (w/w) Sodium lactate in water: b.p. = 108.73 °C.

60 % (w/w) Sodium lactate in water: b.p. = 112.88 °C.

70 % (w/w) Sodium lactate in water: b.p. = 119.43 °C.

This supporting information gives clear experimental evidence that the boiling point of the marketed aqueous solution is highly influenced by the boiling point of pure water. This confirms the QSAR prediction approach chosen as key study for this endpoint.