Registration Dossier
Registration Dossier
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EC number: 203-826-1 | CAS number: 111-02-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Squalane and Squalene
- Author:
- CIR Expert panel
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology 1982 1: 37
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize test
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- EC Number:
- 203-826-1
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Cas Number:
- 111-02-4
- Molecular formula:
- C30H50
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Test material form:
- other: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
Any other information on results incl. tables
The compound did not produce irritation, despite the fact that no attempt was made to wash the eyes after instillation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The compound did not produce irritation
- Executive summary:
The procedure of Draize was used to test undiluted Squalene (0.1 ml) in the eyes of rabbits. The compound did not produce irritation, despite the fact that no attempt was made to wash the eyes after instillation.
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