Registration Dossier
Registration Dossier
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EC number: 201-067-0 | CAS number: 77-90-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- presumably 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only results given. Publication has lack of methodical details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 1.)
3 male albino rabbits were used. The abdomen were closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.
2.)
3 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application.
3.)
Abraded skin:
2 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application. - GLP compliance:
- not specified
Test material
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- no further data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact / abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 1 mL/kg bw (ca. 1000 mg/kg)
- Duration of treatment / exposure:
- 4 - 18 applications
- Observation period:
- 36 h to 2 weeks after last application
- Number of animals:
- 2-3
- Details on study design:
- see above
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritant effects noted
Any other information on results incl. tables
Individual scores were not given. Examination time points: 36 h to 2 weeks after last application.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
In all of the 3 trials there was no indication for skin irritation.
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