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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
presumably 1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Only results given. Publication has lack of methodical details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
1.)
3 male albino rabbits were used. The abdomen were closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.

2.)
3 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application.

3.)
Abraded skin:
2 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application.
GLP compliance:
not specified

Test material

Constituent 1
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
no further data

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact / abraded
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
1 mL/kg bw (ca. 1000 mg/kg)
Duration of treatment / exposure:
4 - 18 applications
Observation period:
36 h to 2 weeks after last application
Number of animals:
2-3
Details on study design:
see above

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritant effects noted

Any other information on results incl. tables

Individual scores were not given. Examination time points: 36 h to 2 weeks after last application.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

In all of the 3 trials there was no indication for skin irritation.