Registration Dossier
Registration Dossier
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EC number: 201-067-0 | CAS number: 77-90-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- presumably 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Methodical details are missing
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3 male albino rabbits were used. The abdomen was closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.
- GLP compliance:
- not specified
- Test type:
- other: Data from a dermal skin irritation study are used, as 1 mL/kg bw (ca. 1000 mg/kg) was administered to rabbits
- Limit test:
- no
Test material
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
abdomen (intact skin) - Duration of exposure:
- daily for 4 days
- Doses:
- 1 mL/kg bw (ca. 1000 mg)
- No. of animals per sex per dose:
- 3 m
- Control animals:
- no
- Details on study design:
- The abdomen was closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- > 1 000 mg/kg bw
- Mortality:
- No evidence
- Clinical signs:
- other: No evidence
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- ATBC did not induce toxic signs when applied to 3 rabbits over 4 consecutive days.
- Executive summary:
In a skin irritation study, which likewise could be used as acute dermal toxicity study (ATBC was applied to rabbits over 4 days at a dosage of 1 mL/kg bw/d; ca. 1000 mg/kg), no signs of toxicity were noted. Therefore it can be concluded that ATBC is not toxic after dermal administration to rabbits at a daily dermal dose of ca. 1000 mg/kg.
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