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EC number: 201-067-0
CAS number: 77-90-7
In a skin
irritation study, which likewise could be used as acute dermal toxicity
study (ATBC was applied to rabbits over 4 days at a dosage of 1 mL/kg
bw/d; ca. 1000 mg/kg), no signs of toxicity were noted. Therefore it can
be concluded that ATBC is not toxic after dermal administration to
rabbits at a daily dermal dose of ca. 1000 mg/kg.
There are no studies available performed according
to current guidelines.
In rats dosed with 10 to 30 mL/kg (ca. 10500 -
31500 mg/kg) no deaths occurred at any dose level throughout the study
(post-observation period: 21 d) (Finkelstein & Gold, 1959; Gold et al.,
1959). Therefore, an oral LD50 value of > 31500 mg/kg can be assumed.
There are no studies available. However, for this
route there is a very low potential for toxicity due to a very high oral
LD50 and also it is unlikely that ATBC is absorbed efficiently through
the skin. In addition data from a skin irritation study, which likewise
could be used as acute dermal toxicity study (ATBC was applied to
rabbits over 4 days at a dosage of 1 mL/kg bw/d; ca. 1000 mg/kg), no
signs of toxicity were noted. Therefore it can be concluded that ATBC
has a very low potential concerning dermal toxicity.
There are no studies available. ATBC is predicted
to present a very low potential for toxicity via inhalation due to the
low vapour pressure and a very high oral LD50.
Based on the available data there is no need to
classify ATBC as acute toxic after oral, dermal or inhalative exposure.
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