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EC number: 203-444-5
CAS number: 106-93-4
The key study for this endpoint was Ágh, 2010. This study was selected basd upon it's reliability (reliability score of 1 according to the criteria of Klimisch et al, 1997) and the age of the study report. The study was conducted according to the OECD 202 guideline using the prefered test species (Daphnia magna) and the prefered exposure time and media (48 hours in freshwater). The study reported a 24 hour EC50 of 15.71 mg/l based upon mobility and a 48 hour EC50 of 11.61 mg/l based upon mobility. Several supporting studies were also available for this endpoint. Herring et al, 1988, was conducted in a similar manner to EU Method C.2 and reported a 72h-LC50 of 50mg/l for Hydra oligactis. Adams et al, 1989, was conducted on Octopuses (3 species) using a novel methodology, and reported a 3h-LC100 of 100mg/l.
As Herring et al, 1988, was conducted in a similar manner to a
recognised testing guideline it was considered to be of sufficient
reliability for presentation as supporting information.
Adams et al, 1989, was reported with a clearly presented methodology and
results section although as it was conducted with a novel methodology on
a species which is typically honored as a vertebrate in the EU no basis
for comparison was available for the study. It was therefore awarded the
reliability score of 4 as insufficient information was available for an
assessment of it's reliability.
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