Registration Dossier
Registration Dossier
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EC number: 202-848-9 | CAS number: 100-40-3
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- other: publication
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature , no details
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- other: benzene (50%)
- Details on exposure:
- -application to shaved dorsal skin (0.1 ml per dose)
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 54 weeks
- Frequency of treatment:
- 3 days/week
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
45 mg substance per application
Basis:
- No. of animals per sex per dose:
- 30 animals
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- no data
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- extensive skin damage
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- one squamous cell carcinoma observed
- Details on results:
- one squamous cell carcinoma observed. The result is attributed by authors to trace concentrations of vinylcyclohexene hydroperoxide (caused by autooxidation of 4-vinylcyclohexene); no carcinogenic effects if oxygen-free material was applied 3 times per week for life to 30 male Swiss mice)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
