Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- intraperitoneal injection up to 250 mg/kg
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: oil - not further specified
- Doses:
- 0.01, 0.025, 0.05, 0.1, and 0.25 g/kg in oil
- No. of animals per sex per dose:
- 3 - 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 100 mg/kg bw
- Remarks on result:
- other: ip injection
- Mortality:
- dose formulation death
0.01 g/kg 0.1 % in oil 0/0/3
0.025g/kg 0.25% in oil 0/3/3
0.05 g/kg 0.5% in oil 1/5/5
0.1 g/kg 1.0 % in oil 3/5/5
0.25 g/kg 2.5% in oil 3/3/3 - Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
as signs of intoxication a reduction of the general condition was observed
Applicant's summary and conclusion
- Executive summary:
method: intraperitoneal injection up to 250 mg/kg
result: LD50 (rat) = ca. 100 mg/kg bw
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