3,4-dichlorophenyl isocyanate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Original reference not available

Principles of method if other than guideline:

DIN 38412, Teil 15

GLP compliance:

no

Analytical monitoring:

no

Test organisms (species):

Leuciscus idus

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

50 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

78.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

125 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC0

Effect conc.:

63 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

95.4 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC100

Effect conc.:

125 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not specified

Executive summary:

In order to investigate the acute toxicity of 3,4-dichlorohenyl isocyanate for fish (Leuciscus idus) a static test was carried out according to DIN 38412, Teil 15. The effect concentration LC50 was found to be 78.3 mg/l after 96 h exposure (Hoechst, 1981).

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

only basic data given

Principles of method if other than guideline:

according to UBA-Verfahrensvorschlag: Letale Wirkung beim Zebrabaerbling Brachydanio rerio (LC0, LC50, LC100, 48-96h), Stand Mai, 1984 which is comparable to the OECD Guideline for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test".

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

35.4 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

42.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: ; geometric mean

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

50 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

no

Remarks:

validity criteria not fullfilled: no analytical monitoring performed, no data on dissolved oxgen and mortality in controls

Executive summary:

Concerning the acute toxicity for fish (Danio rerio) of 3,4-dichlorohenyl isocyanate a static test was carried out according to a national standard method which is comparable to the OECD Guideline for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test". Based on the geometric mean, a LC50 was found to be 42.1 mg/l after 96 h exposure (Bayer 1988).

Description of key information

For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".

Concerning the acute toxicity for fish (Danio rerio) of 3,4-dichlorohenyl isocyanate a static test was carried out according to a national standard method which is comparable to the OECD Guideline for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test". Based on the geometric mean, a LC50 was found to be 42.1 mg/l after 96 h exposure (Bayer 1988).

In order to investigate the acute toxicity of 3,4-dichlorohenyl isocyanate for fish (Leuciscus idus) a static test was carried out according to DIN 38412, Teil 15. The effect concentration LC50 was found to be 78.3 mg/l after 96 h exposure (Hoechst, 1981).