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EC number: -
CAS number: -
Acute CNS effects: NOAEC for in rats: 1500
to 2500 mg/m3 (based primarily on volatility)
Subchronic (13 weeks) neurotoxicity: NOAEC
for rats: >24.3 g/m3 (6646ppm)
Four isoparaffinic hydrocarbon solvent
products differing in predominant carbon number and volatility (C7-8,
C8-9, C10-11, and C11-12) were tested for their acute effects on
locomotor activity and operant performance after inhalation exposure in
mice. For both measures, concentration effect curves were obtained for
30 min exposures using a within-subject design. The more volatile
products, C7-8 and C8-9 isoparaffins, were easily vaporized under the
test conditions. C10-11 isoparaffins were slowly volatilized and C11-12
isoparaffins could not be completely volatilized within the 30 min
exposures, suggesting that acute human exposures may be less
likely. C7-8, C8-9, and C10-11 isoparaffins produced reversible
increases in locomotor activity of mice at 4000 and 6000 ppm and
reversible decreases in rates of schedule controlled operant behavior in
the same concentration range. The locomotor activity and operant
behavior NOAEC for C7-8, C8-9, and C10-11 isoparaffins was determined to
be 1000 ppm. The locomotor activity and operant behavior NOAEC for
C11-12 isoparaffins was determined to be >2000 ppm as C11-12
isoparaffins did not produce acute CNS effects at the maximally
attainable vapor concentrations.
In a battery of neurobehavioral tests, the
NOAECs for acute CNS effects were determined to be >= 2500mg/m3
for cycloparaffins, >=1500mg/m3 for isoparaffins, and
>=1500mg/m3 normal paraffins.
In a 13 week subchronic inhalation study,
the neurotoxicity of light alkylate naphtha distillate (LAND-2; carbon
range C5-C8) was examined in male and female rats. Locomotor activity
and a functional operational battery were performed during the pretest
week, weeks 5, 9, 14, and 18 (recovery group). Other than acute central
nervous system effects, there were no treatment related neurotoxic
effects in any of the treatment groups.
There are no chronic neurotoxicity specific
studies for C9-C14 aliphatic, <2% aromatic hydrocarbon fluids. However,
in a 13 week subchronic inhalation study, the neurotoxicity of light
alkylate naphtha distillate (LAND-2; carbon range C5-C8) was examined in
male and female rats and aside from acute CNS effects, no treatment
related neurotoxic effects found in any of the treatment groups. The
NOAEC was determined to be > 24.3 g/m3 (6646ppm).
Additionally, no neurological effects were reported in the NTP 2 year
carcinogenicity study on Stoddard solvent. Therefore, C9-C14 aliphatic,
<2% aromatic hydrocarbon fluids are not likely to cause neurotoxicity.
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