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EC number: 202-802-8
CAS number: 99-93-4
4-Hydroxyacetophenone was tested for skin irritation under occlusive
conditions using rabbits (UBTL Inc., 1992). The undiluted test substance
was used; testing duration: 4 hours. No skin irritation was recorded.
In another UBTL study (1992), 4-Hydroxyacetophenone was dissolved with
tetrahydrofurane, dimethylsulfoxide, methanol or N,N-dimethylformamide
(30%, 15%, 5% and 3% in either vehicle). Rabbits were applied occlusive
for 4 hours. Based on the results of this experiment,
4-Hydroxyacetophenone does not significantly increase the dermal
irritancy of THF, DMSO, methanol or DMF.
The acute eye irritation was reported by UBTL Inc. (1992). 0.1 g of the
undiluted test substance was used (study duration: 24 h).
Results for the initially treated animal that remained unrinsed: At the
1 h reading corneal opacity 2 was noted with the area involved ranging
from 50 to 75%: Conjunctival redness 2, chemosis 3 and discharge 2 were
also noted. At the 24 h reading corneal opacity 2 was noted with the
area involved ranging from 75 to 100%. Iridial irritation 1 was noted.
Conjunctival redness 2, chemosis 3 and discharge 3 were also noted.
Fluorescein staining of the corneal epithelium was evident with the area
involved ranging from 75-100%.
Hair loss below the lower eyelid was also seen which remained the same
until day 14 when new hair started growing in the area. At the 72 h
reading corneal opacity 2 was noted with the area involved ranging from
50-75%. Iridial irritation 1, conjunctival redness 2, chemosis 2 and
discharge 3 were still noted. Fluorescein staining was evident with the
corneal area involved ranging from 25-50%. On day 21 of the study, the
unrinsed animal was free of ocular irritation. The maximum Draize score
was recorded 48 h after treatment and was 63/110.
Results for the animals of the rinsed group: The rinsed eyes showed
somewhat milder conjunctival effects which were completely resolved by
observation day 7. Slight corneal opacity was reported in 2/3 animals
but only at the 24-h reading. On day 7 of the study, all of the rinsed
animals were free of ocular irritation. According to the authors, the
classification of the test material is considered to be a severe
irritant based upon the maximum total score of 63 calculated for the
initially treated rabbit, that remained unrinsed. The irritation
appeared to be essentially fully reversible within 21 days of treatment.
The rinsing procedure for the additional 3 treated animals appeared to
have reduced the severity and duration of irritation. Based upon the
mean total score of 22 calculated for the three rabbits in the rinsed
group, the classification considered to be as a moderate irritant.
4-Hydroxyacetophenone is classified according to EU Classification,
Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC)
No. 1272/2008 for eye irritation (cat. 2; H319).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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