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EC number: 202-802-8
CAS number: 99-93-4
UBTL Inc. (1992) reported about the acute oral toxicity in rats. Male
and female Sprague-Dawley rats were administered (gavage) the test
substance dissolved in olive oil. Concentrations used were 1000, 2000 or
5000 mg/kg. No mortalities were seen in the lowest dose concentration;
2000 mg/kg - 6/10, 5000 mg/kg 9/10. All animals died within 24 hours.
Clinical signs: Eight of the 5000 mg/kg dose group animals, 10 of the
2000 mg/kg dose group animals and 8 of the 1000 mg/kg dose group animals
exhibited one or more of the following observations during their
respective 14 day observation periods: oral discharge, nasal discharge,
ocular discharge, alopecia, abnormal respiration, tremors, abnormal
stools, lethargy and/or moribundity. Seven of the vehicle control
animals appeared normal throughout the study period. Two of the animals
exhibited abnormal stool on day 0 and an additional animal exhibited
stained coat on days 3-9 of the study period. The acute oral LD50 value
was 2240 mg/kg.
No acute inhalation data are available. Exposure to the test substance
as a 10 u (MMAD) dust at 42 mg/m3 did not lead to mortalities nor to any
other treatment-related findings after 28-day exposure.
An acute dermal LD50 value was found to be > 2000 mg/kg (UBTL Inc.,
1992). Male and female rabbits were covered occlusive with a
concentration of 2000 mg/kg (undiluted test substance). The study
duration was 24 hours. None of the animals died. All rabbits exhibited
one or more of the following observations: abnormal stools, ocular
discharge, erythema and edema at the test site. By day 13, none of the
rabbits had any observable abnormalities. No visible lesions at necropsy
Based on the available data, classification for acute toxicity is not
warranted according to EU Directive 67/548/EEC and EU Classification,
Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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