Registration Dossier
Registration Dossier
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EC number: 202-439-5 | CAS number: 95-65-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- All relevant informations to evaluate the test performance are given in the article. Restrictions: Non GLP, only 2 Strains tested.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Evaluation of Feasibility of Mutagenic Testing of Shale Oil Products and Effluents
- Author:
- by J. L. Epler, T. K. Rao, and M. R. Guerint
- Year:
- 1 979
- Bibliographic source:
- ENVIRON HEALTH PERSPECT 30: 179-84 (1979)
- Reference Type:
- secondary source
- Title:
- No information
- Bibliographic source:
- Hazardous Substances Data Bank (HSDB), a database of the National Library of Medicine's TOXNET system (http://toxnet.nlm.nih.gov) on November 14, 2014.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Ames et. al., Methods for detecting carcinogenes and mutagenes with the Salmonella/mammalian-microsome mutagenicity test; Mutat. Res. 31, 347 (1975)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phenol, dimethyl (xylenole), 3,4
- IUPAC Name:
- Phenol, dimethyl (xylenole), 3,4
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S9 induced with Aroclor 1254
Results and discussion
Test results
- Species / strain:
- other: TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
3,4-DIMETHYLPHENOL WAS NONMUTAGENIC IN TA98 AND TA100 STRAINS OF THE SALMONELLA TYPHIMURIUM HISTIDINE-REVERSION TEST SYSTEM.
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