Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-541-0
CAS number: 3140-73-6
Dose level mg/kg
Number of Animals treated
Deaths During Day of Dosing (hour)
Deaths During Day of Dosing (days)
A study with Spague-Dawley rats was performed according to OECD 401.
After a range finding study the doses 707 mg/kg 1000 mg/kg and 1414
mg/kg were given by gavage. Deaths and clinical signs were observed.
The acute oral median lethal dose LD50 and 95% confidence limit of the
test material were calculated by the method of Thompson W R to be: 870
(812 - 913) mg/kg bodyweight.
No observed / No Dosed
Day(s) of Occurrence
Very slight erythema
Blanching – mild
Blanching - moderate
Blanching – focal/pinpoint
Eschar – mild
Eschar - focal/pinpoint
Very slight edema
Low food consumption
Ancillary irritation on the trunk outside the test site
Based on the result of this study, the acute dermal Median Lethal Dose
(MLD) of 08699 (equivalent to 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine) was
estimated to be greater than 1000 mg/kg in the rabbit. The calculated
primary irritation indes was 6.33 which classifies this dose level as a
severe irritant to the dermal tissue of the rabbit.
Classification acut oral toxicity 4 because of LD50 oral is found to be
870 mg/kg bw in a guideline study.
No classification for acute dermal tox because in a non guideline study
there were no deaths oserved up to 1000mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again