Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline stsudy with sufficient documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
EC Number:
221-541-0
EC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Cas Number:
3140-73-6
Molecular formula:
C5H6ClN3O2
IUPAC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Radiolabelling:
no

Study design

Analytical monitoring:
yes

Results and discussion

Preliminary study:
Aqueous solution of substance prepared with buffer pH 4.0; 7.0 and 9.0 and stored at 25/40/50° C.
Dissipation DT50 of parent compoundopen allclose all
pH:
7
Temp.:
25 °C
DT50:
ca. 1 386 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
40 °C
DT50:
ca. 204 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
50 °C
DT50:
ca. 70
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
25 °C
DT50:
ca. 630 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
40 °C
DT50:
ca. 154 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
50 °C
DT50:
ca. 71 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
25 °C
DT50:
ca. 37 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
40 °C
DT50:
ca. 0 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: to fast for determination
pH:
9
Temp.:
50 °C
DT50:
ca. 0 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: to fast for determination

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
1-Chloro-3,5-Dimethoxy-2,4,6-Triazine is hydrolytically not stable.
Executive summary:

1-Chloro-3,5-Dimethoxy-2,4,6-Triazine is hydrolytically not stable.