Registration Dossier
Registration Dossier
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EC number: 432-400-1 | CAS number: 10102-09-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
For acute toxicity to fish, data are read across from dihydrogen hexahydroxyplatinate, compound with 2 -aminoethanol. The LC50 was determined to be >11.1 mg Pt L-1.
Key value for chemical safety assessment
Additional information
For acute toxicity to fish, data are read across from dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol. In test media, this substance separates into dihydrogen hexahydroxyplatinate and 2-aminoethanol. Both components were analysed in the study. Read across is considered to be appropriate as the platinum-containing component of the substance is a platinum(IV) substance without a chloro ligand. Based on the available ecotoxicity data 2-aminoethanol is expected to be less toxic than platinum and therefore any toxicity is likely to be driven by the platinum component, although some additional toxicity due to 2-aminoethanol cannot be ruled out. There is the potential of additional toxicity due to the 2-aminoethanol component of the substance, however as no effects were observed in the study 2-aminoethanol is not considered to have contributed to the toxicity and read across is considered to be appropriate.
An acute study is available with dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol following OECD test guideline 203, with Danio rerio (Muth-Köhne 2016). Five nominal test concentrations were used, and the test was conducted under semi-static conditions with test media renewal at 48 hours. Analytical verification of test solutions at 0, 48 (aged and fresh solutions) and 96 hours was conducted and analysis of both platinum and 2-aminoethanol was carried out. Mean measured concentrations of 2-aminoethanol in fresh solutions ranged from 55.8 to 58.2% of nominal and in aged solutions ranged from 57.2 to 58.8% of nominal. Mean measured concentrations of platinum were approximately 7% of nominal for fresh and aged test solutions. The test item separated into the two components during the study therefore measured concentrations of the test item as a whole could not be determined. No mortality and no signs of stress or disease were observed in any of the test concentrations. The LC50 was therefore determined to be >11.1 mg Pt L-1, or >55.1 mg 2-aminoethanol L-1.
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