Registration Dossier
Registration Dossier
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EC number: 221-336-6 | CAS number: 3069-29-2
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study planned
- Study period:
- After approval by ECHA
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- Principles of method if other than guideline:
- The study is to be conducted with the hydrolysis product of the registered substance, in view of its hydrolysis rate - see IUCLID Section 6.3, CSR Section 7.2, for further details of the risk assessment approach.
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No soil microorganisms toxicity data are available with N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine (CAS 3069-29-2).
An OECD TG 216 study is proposed with the registration substance.
Toxicity was observed in the aquatic microorganism test (IUCLID Section 6.1.7, CSR Section 7.4), read across from a structural analogue (16 hour EC50 67 mg/L; EC10 25 mg/L (Pseudomonas putida, growth rate) (Diefenbach, 1994)). ECHA guidance Chapter R.7c (ECHA 2017) states “Where inhibition of sewage sludge microbial activity has been observed in Annex VIII testing, a test on soil microbial activity will additionally be necessary for a valid PNEC to be derived.” A soil microorganisms nitrogen inhibition test (OECD 216) is therefore proposed.
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