Registration Dossier
Registration Dossier
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EC number: 220-103-6 | CAS number: 2628-17-3
Endpoint summary
Administrative data
Description of key information
Substance polymerised under the study conditions so skin sensitisation could not be determined.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- direct peptide reactivity assay (DPRA)
- Details on the study design:
- Study design was as required under OECD442C.
- Key result
- Run / experiment:
- other: DPRA
- Parameter:
- other: DPRA
- Value:
- 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- substance polymerised during the study
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Due to the polymerisation of p-vinyl phenol during the study it was not possible to complete the study and hence no classification for skin sensitisation can be determined.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No studies were undertaken as this substance readily polymerises.
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